Is Respiratory Viral Infection an Inciting Event in the Development of Melioidosis? A Systematic Evaluation of Co-infection With Burkholderia pseudomallei and SARS-CoV-2 or Influenza

Genevieve E Martin; Jerry L J Chen; Celeste Woerle; Alexandra Hinchcliff; Robert W Baird; Jane Davies; Bart J Currie

doi:10.1093/ofid/ofae700

Is Respiratory Viral Infection an Inciting Event in the Development of Melioidosis? A Systematic Evaluation of Co-infection With Burkholderia pseudomallei and SARS-CoV-2 or Influenza

Open Forum Infect Dis. 2024 Dec 4;11(12):ofae700. doi: 10.1093/ofid/ofae700. eCollection 2024 Dec.

Authors

Genevieve E Martin^{1

2

3}, Jerry L J Chen^{4

5}, Celeste Woerle¹, Alexandra Hinchcliff¹, Robert W Baird^{2

6}, Jane Davies^{1

2}, Bart J Currie^{1

2}

Affiliations

¹ Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
² Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Australia.
³ Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
⁴ Centre for Disease Control, Public Health Division, NT Health, Darwin, Australia.
⁵ National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.
⁶ Territory Pathology, Royal Darwin Hospital, Darwin, Australia.

Abstract

Respiratory viral infection may increase infection with Burkholderia pseudomallei progressing to clinical disease (melioidosis). This data linkage study evaluated associations between melioidosis and SARS-CoV-2 or influenza. Among 160 melioidosis cases, there was no difference in risk factors, vaccine status, or disease severity between 17 with viral co-infection and 143 without.

Keywords: SARS-CoV-2; influenza; melioidosis.