Human Genetic GLUT1 Deficiency Results in Impaired T Cellular IFN-γ Production

Eur J Immunol. 2024 Dec 13:e202451066. doi: 10.1002/eji.202451066. Online ahead of print.

Affiliations

¹ Department of Pediatrics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
² Institute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.

PMID: 39670678
DOI: 10.1002/eji.202451066

Abstract

GLUT1 deficiency prevents glucose uptake in T cells resulting in lower intracellular ATP generation and IFNy production.

© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.