Purified components of red-edge tea polysaccharide alleviate food allergy in mice by regulating intestinal homeostasis

Yan Li; Yong-Feng Lin; Shao-Han Wang; Zhen Cheng; Wen-Mei Liu; Ze-Hua Zou; Guang-Ming Liu; Qing-Mei Liu

doi:10.1016/j.ijbiomac.2024.138671

Purified components of red-edge tea polysaccharide alleviate food allergy in mice by regulating intestinal homeostasis

Int J Biol Macromol. 2024 Dec 11:288:138671. doi: 10.1016/j.ijbiomac.2024.138671. Online ahead of print.

Authors

Yan Li¹, Yong-Feng Lin¹, Shao-Han Wang¹, Zhen Cheng¹, Wen-Mei Liu², Ze-Hua Zou², Guang-Ming Liu³, Qing-Mei Liu⁴

Affiliations

¹ College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, Fujian, China.
² San Ming MING BAWEI Industry Research Institute, Sanming 353000, China; Changting County Green Economy Ecological Health Industry Research Institute, Longyan 366300, China.
³ College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, Fujian, China; Xiamen Ocean Vocational College, Xiamen, Fujian 361102, China. Electronic address: [email protected].
⁴ College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen 361021, Fujian, China. Electronic address: [email protected].

PMID: 39672399
DOI: 10.1016/j.ijbiomac.2024.138671

Abstract

Previous studies found red-edge tea polysaccharides (RETPS)-3 and 4 have anti-allergic effects. To investigate the anti-food allergy activity of the RETPS-3/4, the ovalbumin-induced Balb/c mouse food allergy model was established. Food allergy symptoms, serum inflammatory factors, spleen and intestinal pathology were analyzed. The proportion of lymphocyte clusters was measured by flow cytometry. The intestinal flora of mice was examined using the 16S rDNA method. The results showed that RETPS-3/4 alleviated food allergy symptoms in mice, relieved intestinal injury, and reduced the contents of ovalbumin-specific immunoglobulin E, mast cell protease, and histamine in the serum of mice. In addition, RETPS-3/4 regulated the proportion of Th2 cells in mouse mesenteric lymph nodes and the abundance of Lactobacillus_muris and Prevotella. These results showed that RETPS-3/4 had anti-food allergy activity and could be developed as a functional anti-food allergy product.

Keywords: Anti-food allergy; Intestinal flora; Red-edge tea polysaccharide.