Background: Neovaginal ileitis is an understudied complication of intestinal vaginoplasty for which no evidence-based treatments exist. Mesalamine has been successfully reported to treat neovaginal colitis and has mixed evidence of efficacy in treating ileal inflammatory syndromes.
Case: We report a 29-year-old female with a history of ileal neovaginoplasty at two years of age for cloacal variant and treatment-refractory neovaginal ileitis with pain and bleeding whose symptoms resolved with treatment with topical mesalamine.
Conclusion: Mesalamine may be a viable treatment for neovaginal ileitis. More data is needed on neovaginal ileitis incidence and treatment, in addition to broader quality of life outcomes after intestinal vaginoplasty.
Keywords: cloacal anomalies; ileal neovagina; intestinal vaginoplasty; mesalamine; neovaginal ileitis.
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