Diuretic strategies in acute decompensated heart failure

Heart Fail Rev. 2024 Dec 15. doi: 10.1007/s10741-024-10473-z. Online ahead of print.

Abstract

Hospitalization for ADHF is linked to poor outcomes, with residual congestion at discharge significantly increasing the risk of HF readmissions and mortality. Diuretic resistance is a major contributor to inadequate decongestion during ADHF treatment. In this review, we discuss various decongestive strategies, emphasizing the management of diuretic resistance. Additionally, we examine the limitations of current decongestion trials and highlight key priorities for future research.

Keywords: ADHF; Diuretic resistance; Neurohormonal activation.

Publication types

  • Review