Four previously undescribed arylalkenyl α-pyrones, designated as crydensiones A‒D (1‒4), were isolated from the twigs and leaves of Cryptocarya densiflora. Their structures were determined through comprehensive spectroscopic analyses together with quantum chemical calculations of electronic circular dichroism (ECD) and nuclear magnetic resonance (NMR) data. All isolates were assessed for cytotoxicity against HCT-116 (colon), A549 (lung), and MDA-MB-231 (breast) cancer cell lines; however, none demonstrated significant activity.
Keywords: Cryptocarya densiflora; Cytotoxicity; quantum chemical calculations; spectroscopic data; α-pyrones.
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