Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience

Gennady Meerovich; Evgeniya Kogan; Igor Romanishkin; Nikolay Zharkov; Sofiya Avraamova; Elena Shchelokova; Ekaterina Akhlyustina; Marina Strakhovskaya; Irina Meerovich; Sofya Demura; Irina Tiganova; Yulia Romanova; Zhi-Long Chen; Igor Reshetov

doi:10.1016/j.pdpdt.2024.104447

Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: Our recent experience

Photodiagnosis Photodyn Ther. 2024 Dec 14:51:104447. doi: 10.1016/j.pdpdt.2024.104447. Online ahead of print.

Affiliations

¹ Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow 115409, Russia.
² I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia.
³ Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia. Electronic address: [email protected].
⁴ Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), Moscow 115409, Russia.
⁵ Lomonosov Moscow State University, Moscow 119991, Russia.
⁶ Research Center of Biotechnology of the Russian Academy of Sciences, A.N. Bach Institute of Biochemistry, Moscow 119071, Russia.
⁷ Huadong Hospital, Fudan University, Shanghai 200040, China.

PMID: 39681293
DOI: 10.1016/j.pdpdt.2024.104447

Abstract

The problem of treating cancer patients with lung cancer has become more difficult due to the SARS-CoV-2 viral infection and concomitant bacterial lesions. The analysis shows that the photodynamic effect of long-wavelength polycationic photosensitizers suppresses the tumor process (including the destruction of cancer stem cells), SARS-CoV-2 coronavirus infection, Gram-positive and Gram-negative bacteria, including those that can cause pneumonia. Therefore, the photodynamic approach using such photosensitizers is promising for the development of an effective treatment method for patients with lung cancer, including those with SARS-CoV-2 infection and bacterial complications.

Keywords: Bacteria; Lung cancer; Photodynamic therapy; SARS-CoV-2.