Recombinant SMN protein synergizes with spinal muscular atrophy therapy to counteract pathological motor neuron phenotypes

Affiliations

• ¹ Laboratory for Research on Neurodegenerative Disorders, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy.
• ² The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology, University of Pavia, 27100, Pavia, Italy.
• ³ Department of Biology and Biotechnology, University of Pavia, 27100, Pavia, Italy.
• ⁴ Humanitas Cardio Center, IRCCS Humanitas Research Hospital, 20089, Rozzano, Milan, Italy.
• ⁵ Institute of Genetic and Biomedical Research (IRGB), UOS of Milan-National Research Council of Italy (CNR), 20138, Milan, Italy.
• ⁶ Department of Physical and Chemical Sciences, University of L'Aquila, 67100, L'Aquila, Italy.
• ⁷ Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
• ⁸ Dubowitz Neuromuscular Centre and National Institute for Health Research, Great Ormond Street Institute of Child Health, Biomedical Research Centre, University College London, London, UK.
• ⁹ Laboratory for Research on Neurodegenerative Disorders, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy. [email protected].