HIF-2α drives TH2 cells

Sci Signal. 2024 Dec 17;17(867):eadv2653. doi: 10.1126/scisignal.adv2653. Epub 2024 Dec 17.

Abstract

Inhibiting HIF-2α impairs the development and function of asthma-promoting helper T cells in mice.

MeSH terms

  • Animals
  • Asthma* / immunology
  • Asthma* / metabolism
  • Basic Helix-Loop-Helix Transcription Factors* / genetics
  • Basic Helix-Loop-Helix Transcription Factors* / immunology
  • Basic Helix-Loop-Helix Transcription Factors* / metabolism
  • Humans
  • Mice
  • Th2 Cells* / immunology
  • Th2 Cells* / metabolism

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • endothelial PAS domain-containing protein 1