Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Jitendra Gupta; Munthar Kadhim Abosaoda; Madhu Shukla; Suhas Ballal; Abhishek Kumar; Mamata Chahar; Suman Saini; Ish Kapila; Alireza Hadpoori

doi:10.1016/j.prostaglandins.2024.106939

Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Prostaglandins Other Lipid Mediat. 2025 Jan:176:106939. doi: 10.1016/j.prostaglandins.2024.106939. Epub 2024 Dec 16.

Authors

Jitendra Gupta¹, Munthar Kadhim Abosaoda², Madhu Shukla³, Suhas Ballal⁴, Abhishek Kumar⁵, Mamata Chahar⁶, Suman Saini⁷, Ish Kapila⁸, Alireza Hadpoori⁹

Affiliations

¹ Institute of Pharmaceutical Research, GLA University, Mathura, UP 281406, India. Electronic address: [email protected].
² College of Pharmacy, The Islamic University, Najaf, Iraq; College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Pharmacy, The Islamic University of Babylon, Babylon, Babylon, Iraq.
³ Marwadi University Research Center, Department of Computer Engineering, Faculty of Engineering & Technology, Marwadi ‎University, Rajkot, Gujarat 360003, India.
⁴ Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be ‎University), Bangalore, Karnataka, India.
⁵ School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh 247341, India; Department of Pharmacy, Arka Jain University, Jamshedpur, Jharkhand 831001, India.
⁶ Department of Chemistry, NIMS Institute of Engineering & Technology, NIMS University ‎Rajasthan, Jaipur, India.
⁷ Department of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of ‎Colleges, Jhanjeri, Mohali, Punjab 140307, India.
⁸ Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and ‎Technology, Chitkara University, Rajpura, Punjab 140401, India.
⁹ Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: [email protected].

PMID: 39689417
DOI: 10.1016/j.prostaglandins.2024.106939

Abstract

Background: There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.

Methods: PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024. Data from RCTs were pooled using the generic inverse variance method and expressed as weighted mean differences (WMD) with 95 % confidence interval (CIs).

Results: Pooled data from 38 RCTs reporting patient outcomes were evaluated for mean effects. Results indicated that soluble fiber significantly altered TG (WMD: -16.97 mg/dL, 95 % CI: -29.16 to -4.78, P = 0.021), HDL-C (WMD: 1.74 mg/dL, 95 % CI: 1.02-2.46, P < 0.001), LDL-C (WMD: -11.14 mg/dL, 95 % CI: -15.41 to -6.87, P < 0.001), and TC (WMD: -13.87 mg/dL, 95 % CI: -17.99 to -9.75, P = 0.027).

Conclusions: Soluble fiber supplementation has the potential to improve lipid profile in patients with T2DM, and may provide a feasible approach for improving metabolic health in T2DM patients.

Keywords: Lipid profile; Meta-analysis; Soluble fiber; Type 2 diabetes.

Publication types

Systematic Review
Meta-Analysis
Review

MeSH terms

Cholesterol, HDL / blood
Diabetes Mellitus, Type 2* / blood
Diabetes Mellitus, Type 2* / diet therapy
Diabetes Mellitus, Type 2* / drug therapy
Dietary Fiber*
Dietary Supplements
Humans
Lipids / blood
Randomized Controlled Trials as Topic*
Triglycerides / blood

Substances

Dietary Fiber
Lipids
Triglycerides
Cholesterol, HDL