BAG-3 Mutation Dilated Cardiomyopathy With Left Ventricular Noncompaction in Young Healthy Adult

Yash B Patel; Wadie David; Milan Terzic; Akanksha Mehla; Tanmay V Swadia

doi:10.1016/j.jaccas.2024.102648

BAG-3 Mutation Dilated Cardiomyopathy With Left Ventricular Noncompaction in Young Healthy Adult

JACC Case Rep. 2024 Nov 20;29(22):102648. doi: 10.1016/j.jaccas.2024.102648.

Authors

Yash B Patel¹, Wadie David², Milan Terzic¹, Akanksha Mehla³, Tanmay V Swadia⁴

Affiliations

¹ Department of Internal Medicine, Trinity Health Ann Arbor, Michigan, USA.
² Department of Cardiology, Ascension Southfield, Michigan, USA.
³ Department of Cardiology, University of Michigan Health Sparrow Hospital, Michigan, USA.
⁴ Trinity Health Michigan Heart, Michigan, USA.

Abstract

Cardiomyopathies are generally divided into ischemic and nonischemic types. Dilated cardiomyopathies, which are a type of nonischemic cardiomyopathy, may have a trait of left ventricular noncompaction. We present the case of a 34-year-old man with new-onset decompensated heart failure and left ventricular noncompaction from a BAG3 (Bcl-2 associated athanogene 3) truncating mutation.

Keywords: cardiomyopathy; genetic disorders; genetics.

Publication types

Case Reports