Rh-Catalyzed trans-Divinylcyclopropane Rearrangement: An Approach to 1,5-Disubstituted 1,4-Cycloheptadienes

Org Lett. 2024 Dec 19. doi: 10.1021/acs.orglett.4c03409. Online ahead of print.

Abstract

Under mild conditions and without the need of inert gas protection, a Rh-catalyzed rearrangement of trans-divinylcyclopropanes to form 1,5-disubstituted 1,4-cycloheptadienes has been developed and is disclosed here. This reaction can expedite the synthesis of challenging seven-membered carbocycles.