Exploring the performance of a DOI-capable TOF-PET module using different SiPMs, customized and commercial readout electronics

Objective.Time resolution is crucial in positron emission tomography (PET) to enhance the signal-to-noise ratio and image quality. Moreover, high sensitivity requires long scintillators, which can cause distortions in the reconstructed images due to parallax effects. This study evaluates the performance of a time-of-flight (TOF)-PET module that makes use of a single-side readout of a4×43.1×3.1×15mm³LYSO:Ce matrix with an array of4×4silicon photomultipliers (SiPMs) and a light guide to extract high-resolution TOF and depth of interaction (DOI) information.Approach.This study assesses the performance of the detector prototype using the commercially available TOFPET2 ASIC and SiPMs from various producers. DOI and TOF performance are compared to results using custom-made NINO 32-chip based electronics.Main results.Using a Broadcom NUV-MT array, the detector module read out by the TOFPET2 ASIC demonstrates a DOI resolution of 2.6 ± 0.2 mm full width at half maximum (FWHM) and a coincidence time resolution (CTR) of 216 ± 6 ps FWHM. When read out using the NINO 32-chip based electronics, the same module achieves a DOI resolution of 2.5 ± 0.2 mm and a CTR of 170 ± 5 ps.Significance.The prototype module, read out by commercial electronics and using state-of-the-art SiPMs, achieves a DOI performance comparable to that obtained with custom-made electronics and a CTR of around 200 ps. This approach is scalable to thousands of channels, with only a deterioration in timing resolution compared to the custom-made electronics, which achieve a CTR of 140 ps using a standard non-DOI module.