Congenital toxoplasmosis: Fewer clinical signs at 3 years of age over the last 15 years but stable risk of materno-fetal transmission

Martine Wallon; Elea Ksiazek; Antoine Journé; Damien Dupont; Jean Menotti; François Peyron; Christine Binquet

doi:10.1093/cid/ciae634

Congenital toxoplasmosis: Fewer clinical signs at 3 years of age over the last 15 years but stable risk of materno-fetal transmission

Clin Infect Dis. 2024 Dec 20:ciae634. doi: 10.1093/cid/ciae634. Online ahead of print.

Authors

Martine Wallon^{1

2}, Elea Ksiazek³, Antoine Journé³, Damien Dupont^{1

2}, Jean Menotti^{1

4}, François Peyron¹, Christine Binquet³

Affiliations

¹ Service de Parasitologie et de Mycologie Médicale, Institut des Agents Infectieux, Hospices Civils de Lyon, Lyon, France.
² Walking Team, Centre for Research in Neuroscience in Lyon, Bron, France.
³ CHU Dijon-Bourgogne, Inserm, Université de Bourgogne, CIC1432, Module Epidémiologie Clinique, Dijon, France.
⁴ Université Claude Bernard Lyon 1, Faculté de Médecine Lyon-Sud Charles Mérieux, UR 3738 - CICLY - Equipe Inflammation et immunité de l'épithélium respiratoire, Lyon, France.

PMID: 39701128
DOI: 10.1093/cid/ciae634

Abstract

Risk and severity of congenital toxoplasmosis were estimated using data from 2,455 consecutive mother/child pairs. Clinical signs at 3 years were halved in the 177 children born since 2009 compared to 1996-2008 (OR=0.49; 95% Confidence interval 0.28-0.85). Maternofetal transmission rates remained stable from 1992 to 2021.

Keywords: Toxoplasma gondii; congenital; incidence; pregnancy; retinochoroiditis; toxoplasmosis.

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