LC3B: A microtubule-associated protein influences disease progression and prognosis

Yan Chen; Hong Yi; Shan Liao; Junyu He; Yanhong Zhou; Yan Lei

doi:10.1016/j.cytogfr.2024.11.006

LC3B: A microtubule-associated protein influences disease progression and prognosis

Cytokine Growth Factor Rev. 2024 Dec 12:S1359-6101(24)00094-7. doi: 10.1016/j.cytogfr.2024.11.006. Online ahead of print.

Authors

Yan Chen¹, Hong Yi², Shan Liao³, Junyu He⁴, Yanhong Zhou⁵, Yan Lei⁶

Affiliations

¹ Department of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
² Research Center of Carcinogenesis and Targeted Therapy, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
³ Department of Pathology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
⁴ Department of Clinical Laboratory, Brain Hospital of Hunan Province (The Second People's Hospital of Hunan Province), Changsha, Hunan 410007, China.
⁵ Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China. Electronic address: [email protected].
⁶ Department of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, China. Electronic address: [email protected].

PMID: 39701849
DOI: 10.1016/j.cytogfr.2024.11.006

Abstract

Microtubule-associated protein 1 light chain 3B (MAP1LC3B, also known as LC3B) is a mammalian homolog of the autophagy-related protein 8 (ATG8) family. It plays a crucial role in cellular autophagy and is involved in several vital biological processes, including apoptosis and differentiation. Additionally, LC3B regulates immune responses. Due to its close association with malignant tumors and neurodegenerative diseases, and its potential as a prognostic indicator and therapeutic target, LC3B has become a significant research focus. This article aims to provide a comprehensive and systematic understanding of LC3B's role and mechanisms in autophagy, its impact on apoptosis and the underlying mechanisms, its regulation of cellular differentiation and transdifferentiation, its modulation of immune and inflammatory responses, the influence of upstream regulatory factors on LC3B's function, and its relevance to disease diagnosis, treatment, and prognosis. The goal is to establish a solid foundation for understanding LC3B's role in cellular processes and its regulatory mechanisms.

Keywords: Autophagy; Carcinoma; LC3B; Pathogenesis; Tumor.

Publication types

Review