The effect of sensory manipulation on the static balance control and prefrontal cortex activation in older adults with mild cognitive impairment: a functional near-infrared spectroscopy (fNIRS) study

Background: This study aimed to investigate the modulatory role of prefrontal cortex (PFC) activity in older adults with mild cognitive impairment (MCI) when sensory cues were removed or presented inaccurately (i.e., increased sensory complexity) during sensory manipulation of a balance task. The research sheds light on the neural regulatory mechanisms of the brain related to balance control in individuals with MCI.

Methods: 21 older adults with MCI (male/female: 9/12, age: 71.19 ± 3.36 years) were recruited as the experimental group and 19 healthy older adults (male/female: 10/9, age: 70.16 ± 4.54 years) as the control group. Participants were required to perform balance tests under four standing conditions: standing on a solid surface with eyes open, standing on a foam surface with eyes open, standing on a solid surface with eyes closed, and standing on a foam surface with eyes closed. Functional Near-Infrared Spectroscopy (fNIRS) and force measuring platform are used to collect hemodynamic signals of the PFC and center of pressure (COP) data during the balance task, respectively.

Results: Under the eyes open condition, significant Group*Surface interaction effects were found in the mean velocity of the COP (MVELO), the mean velocity in the medial-lateral (ML) direction (MVELO_ml) and the 95% confidence ellipse area of the COP (95%AREA-CE). Additionally, significant Group*Surface interaction effect was found in the left orbitofrontal cortex (L-OFC). The significant group effects were detected for three ROI regions, namely the left ventrolateral prefrontal cortex (L-VLPFC), the left dorsolateral prefrontal cortex (L-DLPFC), the right dorsolateral prefrontal cortex (R-DLPFC). Under the eyes closed condition, the significant Group*Surface interaction effects were found in root mean square (RMS), the RMS in the ML direction (RMS_ml) and the 95%AREA-CE. Additionally, significant group effects were detected for five ROI regions, namely R-VLPFC, the left frontopolar cortex (L-FPC), L-DLPFC, R-DLPFC and R-OFC.

Conclusion: Our study emphasizes the role of the PFC in maintaining standing balance control among older adults with MCI, particularly during complex sensory conditions, and provides direct evidence for the role of the PFC during balance control of a clinically relevant measure of balance.

Trial registration: ChiCTR2100044221, 12/03/2021.