Macrophages make "sense" of obesity-driven acidity in the TME

Spenser H Stone; Jeffrey C Rathmell; Jackie E Bader

doi:10.1016/j.chembiol.2024.11.008

Macrophages make "sense" of obesity-driven acidity in the TME

Cell Chem Biol. 2024 Dec 19;31(12):2021-2023. doi: 10.1016/j.chembiol.2024.11.008.

Authors

Spenser H Stone¹, Jeffrey C Rathmell², Jackie E Bader³

Affiliations

¹ Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
² Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.
³ Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: [email protected].

PMID: 39706167
DOI: 10.1016/j.chembiol.2024.11.008

Abstract

Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intratumor acidity resulting in reduced effector function to promote tumor growth.¹.

Published by Elsevier Ltd.

MeSH terms

Animals
Humans
Hydrogen-Ion Concentration
Macrophages* / immunology
Macrophages* / metabolism
Neoplasms / metabolism
Obesity* / metabolism
Receptors, G-Protein-Coupled* / metabolism
Tumor Microenvironment
Tumor-Associated Macrophages / immunology
Tumor-Associated Macrophages / metabolism

Substances

Receptors, G-Protein-Coupled
GPR65 protein, human