Development of the Positive Outcomes through Supported Transition (POST) opioid preventive intervention for youth in the legal system: Study protocol for a sequential multiple assignment randomized trial

Ahnalee M Brincks; Kevin P Haggerty; Alexandria Kolberg; Katie M Albertson; Carolyn A McCarty; Margaret R Kuklinski; Ted Ryle; Kym R Ahrens

doi:10.1016/j.cct.2024.107782

Development of the Positive Outcomes through Supported Transition (POST) opioid preventive intervention for youth in the legal system: Study protocol for a sequential multiple assignment randomized trial

Contemp Clin Trials. 2024 Dec 18:149:107782. doi: 10.1016/j.cct.2024.107782. Online ahead of print.

Authors

Ahnalee M Brincks¹, Kevin P Haggerty², Alexandria Kolberg³, Katie M Albertson³, Carolyn A McCarty⁴, Margaret R Kuklinski², Ted Ryle⁵, Kym R Ahrens⁴

Affiliations

¹ Department of Human Development and Family Studies, Michigan State University, East Lansing, MI, USA. Electronic address: [email protected].
² Social Development Research Group, School of Social Work, University of Washington, Seattle, WA, USA.
³ Seattle Children's Hospital and Research Institute, Seattle, WA, USA.
⁴ Seattle Children's Hospital and Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA.
⁵ Washington State Department of Children, Youth and Families, Olympia, WA, USA.

PMID: 39706330
DOI: 10.1016/j.cct.2024.107782

Abstract

Adolescents and young adults in the legal system (AYALS) are at high risk for opioid use disorder (OUD). Effective, efficient interventions to prevent OUD that support youth as they transition to the community are needed. The Positive Outcomes through Supported Transition intervention trial is designed to identify the optimal intensity and sequence of behavioral skills and case management components for OUD prevention. This sequential, multiple assignment randomized trial addresses three research questions: 1.whether to begin with a high-intensity, broad-scope intervention (Enhanced Adolescent Community Reinforcement Approach; E-ACRA) or a lower intensity intervention (Assertive Community Support; ACS), 2. whether to continue with E-ACRA or step-down to ACS after release, and 3. whether to step-up to E-ACRA or continue ACS for youth reporting problematic substance use after release. Youth committed to state custody will be recruited prior to their release and randomized to E-ACRA or ACS. At five weeks post-release, E-ACRA participants will be re-randomized to E-ACRA or ACS. ACS participants reporting problematic substance use at five weeks will be re-randomized to E-ACRA or ACS. Primary analyses will test the effects of initial intervention (E-ACRA vs. ACS); secondary analyses will test the effects of second-stage interventions. Cost-effectiveness analysis will determine whether the additional resources deployed to E-ACRA are justified economically by the outcomes achieved. Prevention is critical for this population. High-intensity interventions can be burdensome for participants (and agencies) and costly to deliver. This study examines how best to sequence high and low intensity interventions to maximize beneficial outcomes for the most youth. This study's design was pre-registered with clinicaltrials.gov (NCT04901312).

Keywords: Adaptive intervention; Adolescents; Emerging adults; Juvenile justice; Prevention.

Associated data

ClinicalTrials.gov/NCT04901312