[The Drosophila Zinc Finger Protein CG9609 Interacts with the Deubiquitinating (DUB) Module of the SAGA Complex and Participates in the Regulation of Transcription]

Mol Biol (Mosk). 2024 Jul-Aug;58(4):612-618.
[Article in Russian]

Abstract

In previous studies, we found that the zinc finger proteins Su(Hw) and CG9890 interact with the Drosophila SAGA complex and participate in the formation of the active chromatin structure and transcription regulation. In this research, we discovered the interaction of the DUB module of the SAGA complex with another zinc finger protein, CG9609. ChIP-Seq analysis was performed, and CG9609 binding sites in the Drosophila genome were identified. Analysis of binding sites showed that they are localized predominantly at gene promoters. The CG9609 protein has been shown to be involved in the regulation of gene expression.

Keywords: CG9609; DUB-module; SAGA complex; transcription activation; zinc fingers.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Binding Sites
  • Drosophila Proteins* / genetics
  • Drosophila Proteins* / metabolism
  • Drosophila melanogaster* / genetics
  • Drosophila melanogaster* / metabolism
  • Gene Expression Regulation
  • Promoter Regions, Genetic
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription, Genetic*
  • Ubiquitination
  • Zinc Fingers

Substances

  • Drosophila Proteins
  • Trans-Activators