Lipid-laden uterus: Investigating uterine fibroids and lipid association

Uterine Fibroids (UF) are the most common (about 70 % cases) benign gynecological smooth muscle tumors of the uterus in women of reproductive age, characterized by abnormal cholesterol, lipoproteins, and triglyceride levels, and are a major public health concern. Despite its high prevalence, this condition remains complex and poorly understood. These tumors are hormone-dependent and hormones and lipid levels are inversely related. This review delves into the existing literature and critically evaluates studies that explore the potential relationship between lipids in the pathogenesis of uterine fibroids. This review concludes by critically appraising the research gaps in the involvement of lipids and signaling pathways in the pathogenesis of uterine fibroids and future directions for investigating this intriguing biological connection. By elucidating the potential link between uterine fibroids and lipids, this review paves the way for an improved understanding of fibroid pathogenesis, personalized risk assessment, and novel lipid-lowering therapeutic strategies.