Background: This study aims to investigate the relationship between hepatitis B virus (HBV) RNA level and pregnancy outcomes among hepatitis B carriers.
Methods: This study collected pregnant women who attended the Affiliated Hospital of Guizhou Medical University (Guizhou, China) from June 2020 to June 2023. The levels of HBV DNA, HBV RNA, and HBeAg status in HBV carriers were detected. Pregnancy outcomes including intrahepatic cholestasis of pregnancy (ICP), gestational hypertension (GH), pre-eclampsia, gestational diabetes mellitus (GDM), preterm prelabour rupture of membranes (PPROM), mode of delivery, preterm birth, low birth weight (LBW) and macrosomia.
Results: A total of 562 pregnant women were collected, 203 (36.12%) were infected with HBV. Compared with HBsAg negative, HBsAg positive pregnant women had a higher risk of ICP. There were no significant differences in the rates of GDM, GH, pre-eclampsia, PPROM, preterm birth, LBW, macrosomia, and mode of delivery among women in the two groups. Multivariate logistic regression analysis showed that maternal HBV RNA level (OR = 3.814, 95% CI: 2.036~7.142, P< 0.001) was an independent risk factor for ICP in HBsAg-positive pregnant women. The receiver operating characteristics (ROC) curve revealed that the areas under the curve of HBV RNA for prediction of ICP was 0.8652(95% confidence interval 0.7636-0.9669, P< 0.001).
Conclusions: The HBV RNA level has a significant negative impact on pregnancy outcomes. It may serve as an indicator to guide the prevention of ICP and improve maternal health.
Uvod: Ova studija ima za cilj da istraži vezu između nivoa RNK virusa hepatitisa B (HBV) i ishoda trudnoće kod nosilaca hepatitisa B.
Metode: Ova studija je prikupila trudnice koje su pohađale pridruženu bolnicu Medicinskog univerziteta Guizhou (Guizhou, Kina) od juna 2020. do juna 2023. Otkriveni su nivoi HBV DNK, HBV RNK i HBeAg statusa kod HBV nosilaca. Ishodi trudnoće uključujući intrahepatičnu holestazu trudnoće (ICP), gestacijsku hipertenziju (GH), preeklampsiju, gestacijski dijabetes melitus (GDM), prevremeno preporođajnu rupturu membrana (PPROM), način porođaja, prevremeni porođaj, nisku porođajnu težinu (LBV) i makrozomiju.
Rezultati: Prikupljeno je ukupno 562 trudnice, 203 (36,12%) su inficirane HBV-om. U poređenju sa HBsAg negativnim, HBsAg pozitivne trudnice su imale veći rizik od ICP. Nije bilo značajnih razlika u stopama GDM, GH, preeklampsije, PPROM, prevremenog porođaja, LBV, makrozomije i načina porođaja među ženama u dve grupe. Multivarijantna logistička regresiona analiza je pokazala da je nivo HBV RNK kod majke (OR = 3,814, 95% CI: 2,036~7,142, P< 0,001) bio nezavisan faktor rizika za ICP kod HBsAg pozitivnih trudnica. Kriva radnih karakteristika prijemnika (ROC) je otkrila da su površine ispod krive HBV RNK za predviđanje ICP-a bile 0,8652 (95% interval poverenja 0,7636-0,9669, P< 0,001).
Zaključak: Nivo HBV RNK ima značajan negativan uticaj na ishod trudnoće. Može poslužiti kao indikator za prevenciju ICP-a i poboljšanje zdravlja majki.
Keywords: HBV RNA; hepatitis B virus; intrahepatic cholestasis of pregnancy; pregnancy outcomes; serum marker.
2024 Manman Zhang, Xin Liao, Heng Wang, Huan Wu, Baofang Zhang, published by CEON/CEES.