Real-Time Changes in the Comfort of a Toric, Monthly, Soft Contact Lens Over a Long Day of Wear

Purpose: The purpose of this work was to determine the comfort performance of a toric, monthly, silicon hydrogel CL (lehfilcon A; TOTAL30 for Astigmatism) over a long day of wear.

Methods: This was a 1-month, 3-visit, prospective, single-arm study. Adult, 18- to 45-year-old CL wearers with good vision who were minimally symptomatic (CLDEQ-8 scores ≤12) were enrolled. Subjects were required to have astigmatism ranging from -0.75 D to -2.50 D in each eye and were required to wear the study CLs from about 8:00 AM until 12:00 AM each day. Comfort data with the study CL throughout the wear day were collected via text messaging.

Results: A total of 47 subjects who had a mean ± SD age of 29.5 ± 7.0 years were analyzed. Within a specified time point across the month of wear, CL comfort did not vary (all p-value ≥ 0.82), yet CL comfort did decrease across the wear day for all days evaluated (all p-value <0.001). Most subjects found their CLs to be comfortable with only 1.8% of subjects reporting an uncomfortable score at CL application and only 8.5% of subjects reporting an uncomfortable score after 16 hours of CL wear.

Conclusion: A high level of consistency and predictability in comfort was found within the first month of wearing lehfilcon A CLs. This suggests that patients with minimal CL-related discomfort at initial fitting of a lehfilcon A CL may likely tolerate longer wear time with minimal discomfort across the entire month of wear.

Clinical trialsgov id: NCT06052046.