Influence of gut flora on diabetes management after kidney transplantation

BMC Nephrol. 2024 Dec 23;25(1):468. doi: 10.1186/s12882-024-03899-y.

Abstract

Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.

Keywords: Diagnosis; Gut microbiota; Kidney transplantation; Outcome; Post-transplant diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Diabetes Mellitus* / microbiology
  • Gastrointestinal Microbiome* / physiology
  • Humans
  • Kidney Transplantation* / adverse effects
  • Postoperative Complications / etiology
  • Postoperative Complications / microbiology