Versatility of electrospun Janus wound dressings

Electrospun nanofibers produced through single-fluid blending processes have successfully demonstrated their potential as highly effective wound dressings. However, electrospun Janus nanofibers, in which various chambers can be designed to load different active pharmaceutical ingredients into different polymeric matrices, are further exhibiting their versatility for promoting wound healing. This commentary declares that wound dressings always need multiple functional performances to promote wound healing. Janus nanofibers have their unique advantages, with different parts interacting with their environments, thereby providing a versatile platform for developing novel wound dressings. Two recent examples, each with a different preparation strategy for developing novel wound dressings, are discussed, and the promising future of Janus nanofibers in wound dressing applications is highlighted.