A new sesquiterpene from the heartwood of Cordia trichotoma (Vell.) Arráb. ex Steud

A new sesquiterpene, 8,11-epoxy-cadi-3,9-diene (1), along with nine known compounds (2-10), were isolated from the heartwood of Cordia trichotoma. Their structures were elucidated based on NMR spectroscopic data, and by comparison with data previously reported in literature. The hexane extract from the heartwood of C. trichotoma, the EtOH extract from the heartwood of C. trichotoma, the CH₂Cl₂-soluble fraction of the EtOH extract, the EtOAc-soluble fraction of the EtOH extract and the compounds 1-6 have been evaluated as acetylcholinesterase inhibitors, and among these, the extracts and fractions exhibited satisfactory results. In addition, compounds 5, 7, and 8 have not been reported previously from this genus.