Magnesium (Mg), which is predominantly present in cells as a micronutrient, is involved in numerous vital physiological processes, such as DNA repair and energy metabolism. Mg deficiency has been reported to contribute toward the advent and progression of a variety of liver diseases; in particular, these two pathological entities may synergistically act. Given the significant impact and increasing burden of liver diseases on global healthcare resources and economic expenditure, it is tempting to manage Mg insufficiency as novel promising therapeutic strategies. In this review, we comprehensively elaborate on the complicated relationship between Mg deficiency and several contextual liver diseases, with concentrating on the underlying molecular mechanisms.
Keywords: Magnesium; acute liver failure; fatty liver disease; hepatocellular cancer; liver cirrhosis.
Mg deficiency facilitates the advent and progression of various liver diseases in a vicious cycle.Mg supplementation slows the progression of liver disease and decreases the resultant morbidity.The mechanisms how Mg deficiency triggers an inflammatory response, and the standardization of Mg supplementation is under investigation.