Pd/Brønsted Acid Co-catalyzed Dehydrative Coupling of Propargylic Alcohols with Diarylphosphine Oxides

Org Lett. 2024 Dec 25. doi: 10.1021/acs.orglett.4c04586. Online ahead of print.

Abstract

An efficient dehydrative coupling of propargylic alcohols with diarylphosphine oxides to construct tetrasubstituted allenylphosphoryl compounds in the presence of a Pd/Brønsted acid co-catalyst has been developed. As a benefit from the use of a Brønsted acid, this reaction could perform under mild conditions with excellent yields, accommodating a wide range of functional groups. The potential utility of this method has also been demonstrated.