Subsequent bacteremia associated with intravascular catheter colonization with Staphylococcus aureus, Gram-negative rods, and Candida species in children

Hina Hisano; Kensuke Shoji; Toshihiro Matsui; Hiroki Kato; Kana Fukui; Motohiro Kano; Yuji Yamada; Yoshihiro Gocho; Akira Ishiguro

doi:10.1016/j.jiac.2024.102600

Subsequent bacteremia associated with intravascular catheter colonization with Staphylococcus aureus, Gram-negative rods, and Candida species in children

J Infect Chemother. 2024 Dec 24:102600. doi: 10.1016/j.jiac.2024.102600. Online ahead of print.

Authors

Hina Hisano¹, Kensuke Shoji², Toshihiro Matsui³, Hiroki Kato⁴, Kana Fukui⁵, Motohiro Kano⁶, Yuji Yamada⁷, Yoshihiro Gocho⁷, Akira Ishiguro¹

Affiliations

¹ Center for Postgraduate Education and Training, National Center for Child Health and Development, Tokyo, Japan.
² Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan. Electronic address: [email protected].
³ Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
⁴ Division of Critical Care Medicine, Department of Critical Care and Anesthesia, National Center for Child Health and Development, Tokyo, Japan.
⁵ Division of Neonatology, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
⁶ Division of Surgery, Department of Surgical Subspecialties, National Center for Child Health and Development, Tokyo, Japan.
⁷ Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.

PMID: 39725073
DOI: 10.1016/j.jiac.2024.102600

Abstract

Subsequent bacteremia developed in 14% of patients with positive catheter tip cultures but concurrent negative blood cultures. The occurrence of subsequent bacteremia did not differ significantly by pathogens (Staphylococcus aureus, Gram-negative rods [GNR], and Candida spp.). Mortality was higher in patients with GNR and Candida spp. than with S. aureus.

Keywords: Candida spp; Gram-negative rods; Staphylococcus aureus; catheter related blood stream infection; children; subsequent bacteremia.

Copyright © 2024 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. Published by Elsevier Ltd. All rights reserved.