Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule

Mar Drugs. 2024 Nov 29;22(12):536. doi: 10.3390/md22120536.

Abstract

Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (1-5), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6-10). The structures and absolute configuration for new compounds 1-5 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.

Keywords: absolute configuration; anti-inflammatory activity; cembranoid diterpene; soft coral; structural elucidation.

MeSH terms

  • Animals
  • Anthozoa* / chemistry
  • China
  • Circular Dichroism
  • Crystallography, X-Ray
  • Diterpenes* / chemistry
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Lipopolysaccharides / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Nitric Oxide* / metabolism
  • RAW 264.7 Cells

Substances

  • Diterpenes
  • Nitric Oxide
  • Lipopolysaccharides