Regulation of Oxygen in the Tumor Microenvironment Synergizes with Immunotherapy to Suppress Tumor Progression

Shoucheng Wang; Yongjie Chi; Danyang Wang; Kai Zhao; Lianyan Wang

doi:10.3390/jfb15120357

Regulation of Oxygen in the Tumor Microenvironment Synergizes with Immunotherapy to Suppress Tumor Progression

J Funct Biomater. 2024 Nov 25;15(12):357. doi: 10.3390/jfb15120357.

Authors

Shoucheng Wang^{1

2

3

4}, Yongjie Chi^{4

5

6}, Danyang Wang^{4

5

6}, Kai Zhao^{1

2

3}, Lianyan Wang^{4

5

6}

Affiliations

¹ Engineering Research Center of Agricultural Microbiology Technology, Ministry of Education, Heilongjiang University, Harbin 150500, China.
² Key Laboratory of Microbiology, College of Heilongjiang Province, School of Life Sciences, Heilongjiang University, Harbin 150080, China.
³ Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Taizhou University, Taizhou 318000, China.
⁴ Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
⁵ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
⁶ School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.

PMID: 39728157
DOI: 10.3390/jfb15120357

Abstract

Hypoxia represents a crucial characteristic of the tumor microenvironment, which is closely related to cell proliferation, angiogenesis, and metabolic responses. These factors will further promote tumor progression, increase tumor invasion, and enhance tumor metastasis potential. A hypoxic microenvironment will also inhibit the activity of infiltrated immune cells in the tumor microenvironment, leading to the failure of cancer immunotherapy. Additionally, the hypoxic tumor microenvironment contributes to resistance to conventional therapies and leads to unfavorable prognoses. This review discusses advancements in strategies aimed at ameliorating tumor hypoxia within the microenvironment and modulating immune cell responses against tumors.

Keywords: hypoxia; immunosuppression; tumor microenvironment.

Publication types

Review