Healthy lifestyle and metabolic associated steatotic liver disease: a study of the efficacy of fatty liver regression

Background: Obesity is the primary cause of metabolic associated steatotic liver disease (MASLD). Healthy lifestyle management has potential value in the treatment of MASLD.

Methods: A total of 150 patients with MASLD diagnosed at the Health Management Center of our hospital were enrolled and randomly divided into a traditional treatment (control group, n=75) and healthy lifestyle group (observation group, n=75). All patients underwent a three-month intervention. Data on general information, body composition, glucose metabolism, lipid metabolism, and inflammatory factors were analyzed.

Results: The difference in the change of fatty liver grade was statistically significant (P<0.05). There were statistically significant differences in treatment efficiency for physical conditions (P<0.05), including body fat mass (BF), body mass index (BMI), body weight (BW), waist circumference (WC), and waist-to-hip ratio (WHR). Additionally, there were statistically significant differences in treatment efficiency for scales such as the Diet Rating Scale (DRS), Emotional Stress Scale (ESS), and Global Physical Activity Questionnaire (GPAQ) (P<0.05). Differences in treatment efficiency for body fat parameters, including percentage of body fat (PBF), visceral fat area (VFA), aspartate aminotransferase (AST), and diastolic blood pressure (DBP), were also statistically significant (P<0.05). After treatment, statistically significant differences were observed in interferon-γ (IFN-γ), insulin, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and tumor necrosis factor-α (TNF-α) (P<0.05).

Conclusion: Our study indicates that a healthy lifestyle can effectively promote the reduction of fatty liver grade in patients with MASLD, demonstrating positive effects in improving lipid metabolism and inflammatory responses in these patients.