Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples

Dongmei Li; Jiayue Zhou; Zhuxin Chang; Hongwei Zhao; Nan Zhang; Huan Xia; Linyuan Wang; Jie Zhao; Guanggui Yu; Zhongze Fang; Na Sai

doi:10.1016/j.foodchem.2024.142531

Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples

Food Chem. 2024 Dec 18:469:142531. doi: 10.1016/j.foodchem.2024.142531. Online ahead of print.

Authors

Dongmei Li¹, Jiayue Zhou², Zhuxin Chang², Hongwei Zhao³, Nan Zhang², Huan Xia², Linyuan Wang², Jie Zhao², Guanggui Yu², Zhongze Fang⁴, Na Sai⁵

Affiliations

¹ Department of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, 300070 Tianjin, People's Republic of China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
² Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, 300070 Tianjin, People's Republic of China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, People's Republic of China.
³ Affiliated Eye Hospital of Nanchang University, Nanchang, People's Republic of China.
⁴ Department of Toxicology and Health Inspection and Quarantine, School of Public Health, Tianjin Medical University, 300070 Tianjin, People's Republic of China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, People's Republic of China. Electronic address: [email protected].
⁵ Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, 300070 Tianjin, People's Republic of China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, People's Republic of China. Electronic address: [email protected].

PMID: 39729655
DOI: 10.1016/j.foodchem.2024.142531

Abstract

A novel biomimetic molecular imprinted polymer chip with fluorescence (FL) and structural (STR) states, inspired by color patterns of chameleon skin, is fabricated for detecting diethylstilbestrol (DES). The chip features a regularly structured, non-closed-packed (NCP) colloidal photonic crystal (CPC) lattice made monodisperse MIP spheres containing fluorescence poly ionic liquid (FPIL) pigments. The FL color originates from FPIL pigments and is further enhanced by the Purcell effect, while the STR color results from the periodic arrangement of the NCP CPC structure. Upon the addition of DES, the molecular imprinting recognition events of the chip induce bicolored responses. These color variations are observable to the naked eye. Based on a self-correction function of colors, the chip showed direct, sensitive (as low as 0.5 ng/mL), rapid (6 min), selective and stable detection of DES. In sample analysis, the results of DES detected by the chip were by which obtained by the HPLC-MS/MS method.

Keywords: Chameleon skin; Diethylstilbestrol detection; Fluorescence color; Molecular imprinted polymer; Structural color.