Current Approaches to Optimize Donor Heart for Transplantation

Amit H Alam; Candice Y Lee; Manreet K Kanwar; Yasbanoo Moayedi; Alexander M Bernhardt; Koji Takeda; Duc Thinh Pham; Christopher Salerno; Andreas Zuckermann; David D'Alessandro; Victor G Pretorius; John O Louca; Stephen Large; Dawn E Bowles; Scott C Silvestry; Nader Moazami

doi:10.1016/j.healun.2024.12.001

Current Approaches to Optimize Donor Heart for Transplantation

J Heart Lung Transplant. 2024 Dec 25:S1053-2498(24)02012-6. doi: 10.1016/j.healun.2024.12.001. Online ahead of print.

Authors

Amit H Alam¹, Candice Y Lee², Manreet K Kanwar³, Yasbanoo Moayedi⁴, Alexander M Bernhardt⁵, Koji Takeda⁶, Duc Thinh Pham⁷, Christopher Salerno⁸, Andreas Zuckermann⁹, David D'Alessandro¹⁰, Victor G Pretorius¹¹, John O Louca¹², Stephen Large¹³, Dawn E Bowles¹⁴, Scott C Silvestry¹⁵, Nader Moazami¹⁶

Affiliations

¹ Department of Cardiology, New York University Langone Health, New York, NY, USA.
² Department of Thoracic and Cardiovascular Surgery, Allegheny Health Network, Pittsburgh, PA.
³ Cardiovascular Institute at Allegheny Health Network, Pittsburgh PA, USA.
⁴ Ajmera Transplant Centre, University of Toronto, Toronto, ON, Canada.
⁵ Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Hamburg, Germany.
⁶ Division of Cardiac, Thoracic & Vascular Surgery, Department of Surgery, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, USA.
⁷ Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
⁸ Section of Cardiothoracic Surgery, University of Chicago, Chicago, IL, USA.
⁹ Department of Surgery, Medical University of Vienna, Vienna, Austria.
¹⁰ Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
¹¹ Division of Cardiovascular and Thoracic Surgery, University of California San Diego, La Jolla, CA.
¹² University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
¹³ Royal Papworth Hospital Biomedical Campus, Cambridge, CB2 0AY, UK.
¹⁴ Department of Surgery, Duke University Medical Center, Durham, NC.
¹⁵ Department of Cardiothoracic Surgery, University of Arizona College of Medicine, Tucson, AZ.
¹⁶ Department of Cardiothoracic Surgery, NYU Langone Health, New York, NY, USA.

PMID: 39730081
DOI: 10.1016/j.healun.2024.12.001

Abstract

Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement and recent advancements in donor heart procurement technologies. This State-of-the-Art review will explore factors associated with bringing the "ideal" donor heart to the operating room in the contemporary era.

Keywords: Ischemic Reperfusion Injury; organ preservation; organ procurement; primary graft dysfunction.

Publication types

Review