Hyperkaliaemic cardiac arrest in Angelman's syndrome following suxamethonium

BMJ Case Rep. 2024 Dec 27;17(12):e261589. doi: 10.1136/bcr-2024-261589.

Abstract

We present a case of hyperkaliaemic cardiac arrest in a patient with Angelman's syndrome after administration of suxamethonium in rapid sequence intubation. The patient was admitted to the critical care unit in with aspiration pneumonia and intestinal obstruction. They had a cardiac arrest after suxamethonium administration. Potassium level was remarkably high (11.1 mmol/L). ROSC was achieved after 26 min of CPR and resuscitation. We discuss Angelman's syndrome molecular pathology, especially affecting the potassium channels transmission and its relation to suxamethonium in emergency intubation.

Keywords: Anaesthesia; Arrhythmias; Contraindications and precautions; Genetics; Resuscitation.

Publication types

  • Case Reports

MeSH terms

  • Angelman Syndrome* / complications
  • Cardiopulmonary Resuscitation
  • Heart Arrest* / etiology
  • Humans
  • Hyperkalemia* / drug therapy
  • Male
  • Neuromuscular Depolarizing Agents / adverse effects
  • Pneumonia, Aspiration / chemically induced
  • Pneumonia, Aspiration / drug therapy
  • Pneumonia, Aspiration / etiology
  • Rapid Sequence Induction and Intubation
  • Succinylcholine* / adverse effects

Substances

  • Succinylcholine
  • Neuromuscular Depolarizing Agents