Construction and validation of a nomogram model to predict bronchiolitis Mycoplasma pneumoniae pneumonia in children

Sci Rep. 2024 Dec 28;14(1):30758. doi: 10.1038/s41598-024-80906-0.

Abstract

After the cancellation of COVID-19 epidemic control measures in 2023, cases of pediatric bronchiolitis caused by Mycoplasma pneumoniae (MP) have been reported successively, with some children experiencing residual bronchiolitis obliterans (BO). Currently, the diagnosis of bronchiolitis Mycoplasma pneumoniae pneumonia (MPP) primarily relies on high-resolution computed tomography (HRCT). To establish a predictive model for bronchiolitis MPP, a retrospective analysis was conducted. The patients were randomly divided into a training cohort and a validation cohort. The nomogram model was constructed in the training cohort. Finally, the differential, calibration, and clinical applicability of the prediction model were evaluated using both the training and validation cohorts. Logistic stepwise regression analysis identified age, atopy, wheezing, hypoxemia, and pleural effusion as independent predictors of bronchiolitis MPP. These factors were used to construct a nomogram model. This nomogram model serves as a useful tool for predicting the risk of bronchiolitis MPP, which may facilitate individualized early intervention.

Keywords: Mycoplasma pneumoniae; Atopy; Bronchiolitis; Nomogram.

Publication types

  • Validation Study

MeSH terms

  • Bronchiolitis* / microbiology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Mycoplasma pneumoniae / isolation & purification
  • Mycoplasma pneumoniae / pathogenicity
  • Nomograms*
  • Pneumonia, Mycoplasma*
  • Respiratory Sounds
  • Retrospective Studies
  • Tomography, X-Ray Computed