Research progress of mitochondria and cytoskeleton crosstalk in tumour development

Yue Ji; Yingchi Lin; Jing He; Yuanyuan Xie; Wenmin An; Xinyu Luo; Xue Qiao; Zhenning Li

doi:10.1016/j.bbcan.2024.189254

Research progress of mitochondria and cytoskeleton crosstalk in tumour development

Biochim Biophys Acta Rev Cancer. 2024 Dec 26:189254. doi: 10.1016/j.bbcan.2024.189254. Online ahead of print.

Authors

Yue Ji¹, Yingchi Lin², Jing He³, Yuanyuan Xie¹, Wenmin An¹, Xinyu Luo¹, Xue Qiao⁴, Zhenning Li⁵

Affiliations

¹ Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang 110002, Liaoning Province, China.
² Department of Medical Oncology, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China; Provincial key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China; Clinical Cancer Research Center of Shenyang, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China; Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors (China Medical University), Ministry of Education, China.
³ Department of Oral Implantology, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Diseases, Shenyang 110002, Liaoning Province, China.
⁴ Department of Oral Biology, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang 110002, Liaoning Province, China; Department of Central Laboratory, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang 110002, Liaoning Province, China. Electronic address: [email protected].
⁵ Department of Oromaxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Liaoning Province Key Laboratory of Oral Disease, Shenyang 110002, Liaoning Province, China. Electronic address: [email protected].

PMID: 39732178
DOI: 10.1016/j.bbcan.2024.189254

Abstract

During tumour progression, organelle function undergoes dramatic changes, and crosstalk among organelles plays a significant role. Crosstalk between mitochondria and other organelles such as the endoplasmic reticulum and cytoskeleton has focussed attention on the mechanisms of tumourigenesis. This review demonstrates an overview of the molecular structure of the mitochondrial-cytoskeletal junction and its biological interactions. It also presents a detailed and comprehensive description of mitochondrial-cytoskeletal crosstalk in tumour occurrence and development, including tumour cell proliferation, apoptosis, autophagy, metabolic rearrangement, and metastasis. Finally, the application of crosstalk in tumour therapy, including drug combinations and chemoresistance, is discussed. This review offers a theoretical basis for establishing mitochondrial-cytoskeletal junctions as therapeutic targets, and offers novel insights into the future management of malignant tumours.

Keywords: Crosstalk; Cytoskeleton; Mitochondria; Therapy; Tumourigenesis.

Publication types

Review