Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports

Front Med (Lausanne). 2024 Dec 16:11:1479877. doi: 10.3389/fmed.2024.1479877. eCollection 2024.

Abstract

Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This article presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications.

Keywords: alpha-1 antitrypsin deficiency; augmentation therapy; bronchial asthma; emphysema; pregnancy; safety.

Publication types

  • Case Reports

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.