Unraveling IFI44L's biofunction in human disease

Juan Du; Hui Luo; Shuang Ye; Hui Zhang; Zhen Zheng; Kaitai Liu

doi:10.3389/fonc.2024.1436576

Unraveling IFI44L's biofunction in human disease

Front Oncol. 2024 Dec 16:14:1436576. doi: 10.3389/fonc.2024.1436576. eCollection 2024.

Authors

Juan Du^#¹, Hui Luo^#¹, Shuang Ye¹, Hui Zhang¹, Zhen Zheng¹, Kaitai Liu¹

Affiliation

¹ The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.

^# Contributed equally.

Abstract

Interferon-induced protein 44-like (IFI44L) is regarded as an immune-related gene and is a member of interferon-stimulated genes (ISGs). They participate in network transduction, and its own epigenetic modifications, apoptosis, cell-matrix formation, and many other pathways in tumors, autoimmune diseases, and viral infections. The current review provides a comprehensive overview of the onset and biological mechanisms of IFI44L and its potential clinical applications in malignant tumors and non-neoplastic diseases.

Keywords: biomarker; diagnosis; immune response; interferon-induced protein 44-like (IFI44L); therapeutic target; tumor.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by grants from the Project of NINGBO Leading Medical & Health Discipline (No. 2022-F01); Medical and Health Research Project of Zhejiang Province, Grant/Award (2024KY1469).