Coronavirus disease-2019 (Covid-19) caused by the virus SARS-CoV 2 is a major health problem across the globe currently. Bangladesh is also defying this highly infectious disease with an exponentially rising number of cases across the country. This study was designed to observe the socio-demographic characteristics, clinical presentation and treatment outcome of Covid-19 cases in Bangladesh. In this cross-sectional observational study, a total of 334 Covid-19 positive patients were enrolled following selection criteria who were tested RT-PCR for Covid-19 infection in the Department of Microbiology, Mymensingh Medical College, Bangladesh from January 2021 to December 2021. A telephonic interview with a pre-tested semi-structured questionnaire was used to collect data. Among 334 Covid-19 positive patients, males (72.46%) were more affected than females (27.54%). The mean age was 36.32±12.369 years. Most of the cases resided in urban areas (83.53%). Approximately 13.77% were asymptomatic and 86.23% were symptomatic. Out of 334 patients, 98 (29.34%) patients had comorbidities, among which 76(22.75%) patients had a single co-morbid condition and 22(6.59%) patients had multiple comorbidities. Fever (83.53%), cough (52.99%) and altered smell and taste (40.71%) were the most common presenting symptoms. Antibiotics (91.32%) and paracetamol (83.53%) were the most commonly used drugs. Approximately 80.24% were isolated in their homes, while 5.39% were treated at Covid-19-dedicated hospitals. Finally, 13.77% were discharged without complications and 2.69% died. This investigation revealed that males became more infected than females. The majority of the cases resided in urban areas. Most of the infected patients were isolated at homes, whereas one-fifth of them were treated at different types of hospitals. Clinically, antibiotics were the most commonly used medication. However, the majority of the cases were discharged from the hospital without complications.