Two New Cardiac Glycosides from Streblus asper

Ai-Jun Hou; Yun-Xuan He; Qin Ouyang; Jin-Chang Huang; Chun Lei

doi:10.1002/cbdv.202403344

Two New Cardiac Glycosides from Streblus asper

Chem Biodivers. 2024 Dec 30:e202403344. doi: 10.1002/cbdv.202403344. Online ahead of print.

Authors

Ai-Jun Hou¹, Yun-Xuan He², Qin Ouyang², Jin-Chang Huang³, Chun Lei²

Affiliations

¹ Fudan University, Department of Pharmacognosy, School of Pharmacy, 826 Zhang Heng Road, 201203, Shanghai, CHINA.
² Fudan University, School of Pharmacy, Jinke Road 3728, Shanghai, CHINA.
³ Shanghai Jiaotong University: Shanghai Jiao Tong University, School of Pharmaceutical Sciences, Dongchuan Road 800, Shanghai, CHINA.

PMID: 39739764
DOI: 10.1002/cbdv.202403344

Abstract

Two undescribed cardiac glycosides, strasperoside K (1) and L (2), together with five known analogues (3-7), were isolated from Streblus asper Lour. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. The inhibitory activities of isolated compounds against porcine epidemic diarrhea virus (PEDV) and six strains of pathogenic bacteria were evaluated.

Keywords: Moraceae; Streblus asper Lour; cardiac glycosides.