Benzoylaconine: Potential Therapeutic Agent for Cardiovascular Diseases From Fuzi

Cardiovasc Ther. 2024 Jul 3:2024:4878103. doi: 10.1155/2024/4878103. eCollection 2024.

Abstract

Modern pharmacological studies have elucidated the presence of aconitine (AC) alkaloids, polysaccharides, and saponins as the primary bioactive constituents of Fuzi. Among these, benzoylaconine, a pivotal active compound, demonstrates notable pharmacological properties including antitumor, anti-inflammatory, and cardiovascular protective effects. In recent years, benzoylaconine has garnered significant attention in basic research on heart diseases, emerging as a focal point of investigation. This paper presents a comprehensive review of the pharmacological effects of benzoylaconine, alongside an overview of advancements in metabolic characterization. The objective is to furnish valuable insights that can serve as a cornerstone for further exploration, utilization, and advancement of benzoylaconine in pharmacological research.

Keywords: anti-inflammation; benzoylaconine; cardiac diseases; pharmacokinetics; pharmacological effects.

Publication types

  • Review

MeSH terms

  • Aconitine / analogs & derivatives
  • Animals
  • Cardiovascular Agents / adverse effects
  • Cardiovascular Agents / therapeutic use
  • Cardiovascular Diseases* / drug therapy
  • Diterpenes
  • Drugs, Chinese Herbal* / adverse effects
  • Drugs, Chinese Herbal* / therapeutic use
  • Humans
  • Signal Transduction / drug effects

Substances

  • Drugs, Chinese Herbal
  • benzoylaconine
  • fuzi drug herbal
  • Cardiovascular Agents
  • Aconitine
  • Diterpenes