Pd(OAc)2-Catalyzed Synthesis of Imidazo[1,2- f]phenanthridines via a Sequential Ullmann Coupling and Oxidative Coupling Dehydrogenation

J Org Chem. 2025 Jan 10;90(1):1-7. doi: 10.1021/acs.joc.4c00795. Epub 2025 Jan 1.

Abstract

The Ullmann coupling and oxidative coupling dehydrogenation reactions have occurred sequentially, catalyzed by Pd(OAc)2, which unexpectedly yielded fused imidazo[1,2-f]phenanthridine derivatives in good to high yields. Structural analysis of the intermediate and final products indicated that the protocol did not include C-H and N-H arylation.