Engraft: A Collaborative Learning Health Network for Enhanced Transplant and Cellular Therapy Outcomes

Christopher E Dandoy; Jeffery J Auletta; Priscila Badia; Alan Bidgoli; Nancy M Daraiseh; Anna M DeSalvo; Javier Diaz; Stella M Davies; Kathleen Demmel; Eleanor Cook; John A Craddock; John Huber; Megan Sampson; Taylor J Fitch; Karis French; Sonata Jodele; Samantha M Jaglowski; Malika A Kapadia; Nandita Khera; Georgia R Kent; Kathryn S Leung; Leslie E Lehmann; Wayne H Liang; Steffani Maier; Adam Nelson; Miki Nishitani; Dónal O'Mathúna; Darren J Johnson; Kathleen Magee; Ahna Pai; Loretta M Parker; Rachel Phelan; Preston Epling; Seth Rotz; Baheyeldin M Salem; Alana Snyder; Mark Juckett; David Hartley

doi:10.1016/j.jtct.2024.12.017

Engraft: A Collaborative Learning Health Network for Enhanced Transplant and Cellular Therapy Outcomes

Transplant Cell Ther. 2024 Dec 30:S2666-6367(24)00836-4. doi: 10.1016/j.jtct.2024.12.017. Online ahead of print.

Authors

Christopher E Dandoy¹, Jeffery J Auletta², Priscila Badia³, Alan Bidgoli⁴, Nancy M Daraiseh⁵, Anna M DeSalvo⁶, Javier Diaz⁷, Stella M Davies³, Kathleen Demmel³, Eleanor Cook⁸, John A Craddock⁹, John Huber³, Megan Sampson¹⁰, Taylor J Fitch⁴, Karis French³, Sonata Jodele³, Samantha M Jaglowski¹¹, Malika A Kapadia¹², Nandita Khera¹³, Georgia R Kent³, Kathryn S Leung⁴, Leslie E Lehmann¹², Wayne H Liang⁴, Steffani Maier³, Adam Nelson¹⁴, Miki Nishitani¹², Dónal O'Mathúna¹⁵, Darren J Johnson¹⁶, Kathleen Magee⁹, Ahna Pai¹⁷, Loretta M Parker¹⁸, Rachel Phelan¹⁹, Preston Epling²⁰, Seth Rotz²⁰, Baheyeldin M Salem⁹, Alana Snyder³, Mark Juckett²¹, David Hartley²²

Affiliations

¹ Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: [email protected].
² Center for International Blood and Marrow Transplant Research NMDP, Minneapolis, MN; Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH.
³ Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio.
⁴ Aflac Cancer and Blood Disorders Center at Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA.
⁵ University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
⁶ Center for International Blood and Marrow Transplant Research NMDP, Minneapolis, MN.
⁷ Children's Health, Wilmington, DE.
⁸ Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati College of Medicine, Cincinnati, Ohio; Sydney Children's Hospital, Sydney, Australia.
⁹ Center for Cell and Gene Therapy Texas Children's Hospital, Department of Pediatrics Baylor College of Medicine, Houston, TX.
¹⁰ Northeast Ohio Medical university, Pediatric Hematology, Oncology and Bone Marrow Transplant, Akron Children's, Akron, OH.
¹¹ Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI.
¹² Division of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pediatrics, Harvard University Medical School, Boston, MA.
¹³ Division of Hematology and Oncology, Mayo Clinic Arizona, Phoenix, AZ.
¹⁴ Sydney Children's Hospital, Sydney, Australia.
¹⁵ The Ohio State University, Columbus, OH.
¹⁶ Boston Childrens Hospital.
¹⁷ Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH.
¹⁸ Children's of Alabama, The University of Alabama at Birmingham, Birmingham, AL.
¹⁹ Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI; Division of Hematology, Oncology, and Blood and Marrow Transplant, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
²⁰ Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic, Cleveland, OH.
²¹ Division of Hematology, Oncology, and Transplantation, University of Minnesota Medical School, Minneapolis, MN.
²² University of Cincinnati College of Medicine, Cincinnati, Ohio; James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

PMID: 39743208
DOI: 10.1016/j.jtct.2024.12.017

Abstract

The Engraft Learning Health Network (LHN) aims to improve outcomes for patients undergoing transplant and cellular therapy (TCT) through a collaborative, data-driven approach. Engraft brings together diverse stakeholders, including clinicians, patients, caregivers, and institutions, to standardize best practices and accelerate the dissemination of innovations in TCT care. By establishing a multicenter, real-world clinical registry focused on rapid-cycle quality improvement (QI) and implementation research, Engraft seeks to reduce variability in clinical practice to improve TCT outcomes across centers. Initial efforts have centered on developing QI toolkits, sharing de-identified patient data, and building consensus around best practices to reduce non-relapse mortality and improve survivorship. A distinctive feature of Engraft is its commitment to engaging patients and caregivers as equal partners in the network's direction. This manuscript outlines the network's design, early successes, and future goals.

Keywords: Hematopoietic Stem Cell Transplant; Immune Effector Cell Therapy; Implementation Science; Learning Health Network; Non-Relapse Mortality; Quality Improvement.