Mesenchymal stem cells (MSC) possess unique immunomodulatory properties and have enormous potential in the treatment of graft-versus-host disease (GVHD). However, the low implantation and survival rates of MSC in vivo, coupled with their weak immunosuppressive functions, have resulted in unstable clinical efficacy in the treatment of GVHD. Preconditioning of MSC with hypoxia, active molecules and gene modification can enhance the function of MSC and improve the implantation rate, survival rate and therapeutic effect of MSC. This review summarized the strategies for enhancing the efficacy of MSC in the treatment of hematopoietic stem cell transplantation complicated with GVHD in recent years, aiming to provide new strategies for optimizing the application of MSC in the prevention and treatment of GVHD.
题目: 间充质干细胞治疗造血干细胞移植后移植物抗宿主病的增效策略研究进展.
摘要: 间充质干细胞（MSC）具有独特的免疫调节特性，在治疗移植物抗宿主病（GVHD）方面具有较大的潜力。然 而，MSC体内植入率和存活率低，免疫抑制能力弱，导致临床应用MSC治疗GVHD时疗效不够稳定。对MSC进行低氧预处理、活性分子预处理和基因修饰可增强MSC的功能，提升MSC的植入率、存活率和治疗效果。本文就近年来MSC治疗造血干细胞移植并发GVHD的增效策略的最新研究进展作一综述，旨在为优化MSC在防治GVHD中的应用提供新策略。.
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease; mesenchymal stem cells; strategies for enhancing the efficacy.