Metabolic reprogramming in lung cancer and its clinical implication

Qingqiu Huang; Lisha Fan; Mingjing Gong; Juntong Ren; Chen Chen; Shenglong Xie

doi:10.3389/fphar.2024.1516650

Metabolic reprogramming in lung cancer and its clinical implication

Front Pharmacol. 2024 Dec 18:15:1516650. doi: 10.3389/fphar.2024.1516650. eCollection 2024.

Authors

Qingqiu Huang^#¹, Lisha Fan^#², Mingjing Gong^#³, Juntong Ren⁴, Chen Chen⁵, Shenglong Xie¹

Affiliations

¹ Department of Thoracic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Sichuan Province Revolutionary Disable Armyman Rehab, The First Veterans Hospital Of Sichuan Province, Chengdu, China.
⁴ School of Pharmaceutical Sciences, Guizhou University, Guiyang, China.
⁵ Department of Outpatient, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

^# Contributed equally.

Abstract

Lung cancer has posed a significant challenge to global health, and related study has been a hot topic in oncology. This article focuses on metabolic reprogramming of lung cancer cells, a process to adapt to energy demands and biosynthetic needs, supporting the proliferation and development of tumor cells. In this study, the latest studies on lung cancer tumor metabolism were reviewed, including the impact of metabolic products and metabolic enzymes on the occurrence and development of lung cancer, as well as the progress in the field of lung cancer treatment targeting relevant metabolic pathways. This provides some promising potential directions into exploring lung cancer tumor metabolism and helps researchers to better understand lung cancer.

Keywords: amino acid metabolism; glucose; lipid metabolism; lung cancer; metabolic reprogramming.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Science and Technology Department of Sichuan Province - Key R&D project (2023YFS0305).