Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review

Psychopharmacol Bull. 2025 Jan 1;55(1):26-36.
  • PMID: 39744414
  • PMCID: PMC11626918 (available on )

Abstract

Gabapentin and pregabalin are widely used in the management of neuropathic pain though their prescribing patterns, effectiveness, and safety profiles remain topics of ongoing research. This retrospective chart review analyzed the prevalence of gabapentinoid use in a chronic pain clinic over a one-year period from May 1, 2023, to April 30, 2024. The study examined patient records from four pain management physicians, focusing on those prescribed gabapentin or pregabalin. Of the 2,395 patients reviewed, 478 (19.96%) were prescribed gabapentin, while 236 (9.85%) received pregabalin. Combined, 714 patients (29.81%) were managed with either medication, highlighting the significant role gabapentinoids play in chronic pain treatment. The study found that gabapentin was prescribed more frequently than pregabalin. Although both medications are effective for neuropathic pain, their use comes with notable side effects, including dizziness, somnolence, and, in some cases, an increased risk of suicidal ideation. This review underscores the importance of careful patient monitoring and individualized treatment approaches when prescribing gabapentinoids. Future research across multiple sites and further stratification of patient demographics would enhance understanding of gabapentinoid use in clinical practice.

Keywords: chronic pain management; gabapentin; gabapentinoids; neuropathic pain; pregabalin; prescribing patterns.

MeSH terms

  • Adult
  • Aged
  • Analgesics* / administration & dosage
  • Chronic Pain* / drug therapy
  • Female
  • Gabapentin* / administration & dosage
  • Gabapentin* / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Neuralgia / drug therapy
  • Pain Management / methods
  • Practice Patterns, Physicians'* / statistics & numerical data
  • Pregabalin* / administration & dosage
  • Pregabalin* / adverse effects
  • Retrospective Studies

Substances

  • Gabapentin
  • Pregabalin
  • Analgesics