SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy

Front Immunol. 2024 Dec 18:15:1510942. doi: 10.3389/fimmu.2024.1510942. eCollection 2024.

Abstract

Introduction: Multiple myeloma (MM) is an uncontrolled plasma cell proliferation in the bone marrow, leading to immune dysregulation with impaired humoral immune responses. Conversely, cellular-based responses play a vital role in MM patients. However, the extent and duration of cellular-induced protection remain unclear to date. Here, immunomodulatory drugs (IMiDs) like Lenalidomide (Lena) become interesting, as they may have stimulatory effects on T-cell functioning.

Methods: In this study we investigated immune responses elicited by COVID-19 vaccine or infection comparing 43 healthy volunteers (avg. 35y, 72.1% female, 81.4% previously COVID-19 infected), with 41 MM patients under Lena maintenance therapy (avg. 63.8y, 51.2% female, 61% previously COVID-19 infected). Humoral responses to SARS-CoV-2 spike (S), spike-RBD, and nucleocapsid (N) were measured via ELISA in subjects' plasma. Freshly isolated PBMCs, incubated with SARS-CoV-2 peptides (N, S), activation induced marker (AIM) assays and flow cytometry, allowed us to assess cellular responses (CD8+ T, T(F)H: CD4+ T (follicular) helper).

Results: Whereas healthy controls showed significant better humoral responses (N IgA p<0.001), T cell responses were robust in the MM group (higher S-act. TH, p<0.001). Stratified by COVID-19 status, the MM group showed higher N-act. TH (p=0.03). These results were unchanged comparing a Lena intake with Lena break around vaccination.

Discussion: Taken together, MM patients under Lena therapy exhibit weakened antibody production but present a robust T cell response following SARS-COV-2 infection or vaccination. Our results highlight the importance of vaccination in this subgroup and moreover, argue against a Lena intake break around the time of vaccination.

Keywords: cellular immune responses; immunomodulatory therapy; lenalidomide; multiple myeloma; vaccine response.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Viral* / blood
  • Antibodies, Viral* / immunology
  • COVID-19 Vaccines / immunology
  • COVID-19* / immunology
  • Female
  • Humans
  • Immunity, Humoral / drug effects
  • Immunomodulating Agents / pharmacology
  • Immunomodulating Agents / therapeutic use
  • Lenalidomide* / administration & dosage
  • Lenalidomide* / therapeutic use
  • Maintenance Chemotherapy
  • Male
  • Middle Aged
  • Multiple Myeloma* / drug therapy
  • Multiple Myeloma* / immunology
  • SARS-CoV-2* / immunology
  • Spike Glycoprotein, Coronavirus* / immunology

Substances

  • Lenalidomide
  • Antibodies, Viral
  • Spike Glycoprotein, Coronavirus
  • COVID-19 Vaccines
  • spike protein, SARS-CoV-2
  • Immunomodulating Agents

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This project was partly funded by the German Research Foundation (DFG) – 467578951. We acknowledge support from the Open Access Publication Fund of the University of Tübingen.