Orthopaedic surgery has a higher risk of iatrogenic nerve injury than other surgical specialties. The initial management depends on the etiology, which requires early recognition and an appreciation for the injury. Three perspectives are given to guide the surgeon through the initial management of these devastating complications. An orthopaedic surgeon with a knowledge of case law emphasizes the importance of clear documentation and frequent communication with the patient. An anesthesiologist discusses the improvements in regional anesthesiology and the risks inherent in motor-sparing blocks. Finally, a peripheral nerve surgeon offers next steps in confirming the diagnosis and the importance of prompt referral.