Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein

Affiliations

• ¹ Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
• ² Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
• ³ Institute for Systems Biology, Seattle, WA, USA.
• ⁴ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
• ⁵ Department of Molecular Microbiology and Immunology and Johns Hopkins Malaria Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
• ⁶ Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, OR, USA.
• ⁷ Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
• ⁸ Bioinformatics & Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
• ⁹ Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
• ¹⁰ Department of Biology, The Catholic University of America, Washington, DC, USA.
• ¹¹ Seattle Children's Research Institute, Seattle, WA, USA.
• ¹² Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
• ¹³ Antigen Discovery, Incorporated, Irvine, CA, USA.
• ¹⁴ General Dynamics Information Technology, Inc., Falls Church, VA, USA.
• ¹⁵ Agile Vaccines and Therapeutics Department, Naval Medical Research Command, Silver Spring, MD, USA.
• ¹⁶ Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
• ¹⁷ Mali International Center of Excellence in Research, University of Sciences, Technique and Technology of Bamako, Bamako, Mali.
• ¹⁸ Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
• ¹⁹ The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
• ²⁰ The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.