The Efficacy of Heparin and Nitroglycerin in Managing Vascular Embolism Complications from Polycaprolactone (PCL) Fillers: A Clinical Study

Background: The use of PCL fillers has increased due to their long-lasting effects and collagen stimulation properties. However, managing vascular embolisms caused by PCL fillers is challenging due to the inability to dissolve them quickly. This study builds upon our previous findings from animal studies, which provided valuable insights into the management of PCL-related vascular complications.

Objectives: To evaluate the efficacy of heparin and nitroglycerin in managing vascular embolism complications resulting from PCL fillers in a clinical setting.

Methods: A retrospective clinical study involves 10 patients with vascular embolisms following PCL injections. Treatments included heparin and nitroglycerin administration, imaging for embolism assessment and follow-up ranging from 1 month to 1 year.

Results: The study demonstrated a significant improvement in blood flow and reduction in ischemia with minimal adverse reactions.

Conclusions: Heparin and nitroglycerin are effective in managing PCL-related vascular embolisms, providing a viable alternative for clinicians.

Level of evidence iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .